Dasania (Dasatinib) is a tyrosine kinase inhibitor used primarily for the treatment of certain types of leukemia. It is effective in targeting specific proteins that contribute to the growth of cancer cells, particularly in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) with the Philadelphia chromosome mutation.

Uses

Chronic Myeloid Leukemia (CML):

• Effective in newly diagnosed patients as well as those resistant or intolerant to prior therapies like Imatinib.

Acute Lymphoblastic Leukemia (ALL):

• Used in patients with Philadelphia chromosome-positive (Ph+) ALL.

Dasatinib inhibits multiple tyrosine kinases, including BCR-ABL, which is an abnormal protein produced by the Philadelphia chromosome mutation. This inhibition blocks the proliferation of cancer cells.

Side Effects

Common side effects include:

1. Nausea and vomiting
2. Fatigue
3. Diarrhea
4. Fluid retention (edema)
5. Muscle or joint pain

Serious side effects:

• Severe bleeding
• Pulmonary arterial hypertension
• Infections due to decreased white blood cell count

Precautions

1. Pregnancy: Not recommended during pregnancy; use effective contraception.
2. Liver and Kidney Function: Regular monitoring is advised.
3. Drug Interactions: Avoid combining with drugs that inhibit or induce CYP3A4.
4. QT Prolongation: Patients with a history of heart issues should take precautions.

Dosages

• Chronic Myeloid Leukemia: 100 mg once daily orally.
• Acute Lymphoblastic Leukemia: 140 mg once daily orally.
• Dose adjustments may be necessary based on tolerance or side effects.

Storage

• Store at room temperature away from moisture and direct sunlight.