Buselin is a synthetic gonadotropin-releasing hormone (GnRH) agonist used primarily in the treatment of hormone-sensitive conditions. It is particularly effective in managing prostate cancer, endometriosis, and uterine fibroids. By modulating hormone levels, Buselin helps reduce disease progression and alleviate symptoms. Buselin injection is a critical therapy for managing hormone-sensitive conditions. By effectively modulating hormone levels, it offers significant benefits in reducing disease progression and improving quality of life. Proper monitoring and adherence to treatment guidelines ensure optimal outcomes.

Indications

1. Prostate Cancer:
   • As part of androgen-deprivation therapy to reduce testosterone production and slow tumor growth.
2. Endometriosis:
   • To relieve pain and reduce endometrial lesions.
3. Uterine Fibroids:
   • As a preoperative treatment to shrink fibroids.
4. Assisted Reproductive Techniques (ART):
   • To control ovarian function during in-vitro fertilization (IVF).

Buselin acts as a GnRH agonist. Initially, it stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary increase in sex hormone levels. With continuous administration, it suppresses the pituitary gland, reducing gonadotropin secretion and consequently lowering testosterone or estrogen levels.

Dosage and Administration

• Prostate Cancer:
  Initial dose: 0.5 mg subcutaneously 3 times daily for 7 days, followed by a maintenance dose of 1.8 mg intramuscularly every 4 weeks.

• Endometriosis/Uterine Fibroids:
  Typically 0.5-1 mg daily, administered subcutaneously for 6 months.

• ART/IVF:
  Dosage varies based on protocol and individual patient needs.

Side Effects

Common Side Effects:

• Hot flashes
• Headache
• Nausea
• Injection site reactions
• Decreased libido
• Mood changes

Serious Side Effects:

• Bone density loss with long-term use
• Cardiovascular issues (rare)
• Allergic reactions (rash, swelling, or difficulty breathing)
• Initial symptom flare-up in prostate cancer

Precautions and Warnings

1. Hormone Flare: In prostate cancer, initial use may temporarily worsen symptoms; concurrent anti-androgen therapy may be necessary.
2. Bone Health: Prolonged use may lead to osteoporosis; calcium and vitamin D supplementation or bone health monitoring is advised.
3. Pregnancy and Lactation: Contraindicated in pregnant or breastfeeding women due to potential harm to the fetus or infant.
4. Drug Interactions: May interact with medications affecting hormone levels or those with similar metabolic pathways.

Storage Instructions

• Store at 2-8°C (refrigerator).
• Protect from light.
• Do not freeze.