Ruparib 300mg Tablet

 120 people have bought this recently
60 Tablet in 1 Bottle Out of Stock
₹ 51096.59
60 Tablet 1 Bottle ₹ 51096.59
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Ruparib 300mg Tablet

60 Tablet in 1 Bottle
₹ 51096
60 Tablet | 1 Bottle
₹ 51096
120 people have bought this recently
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Ruparib Information

Ruparib brand contains Rucaparib is an orally available poly (ADP-ribose) polymerase (PARP) inhibitor used in the treatment of certain types of ovarian, prostate, and other cancers. It is designed to exploit deficiencies in DNA repair mechanisms, particularly in patients with BRCA1/BRCA2 mutations and other homologous recombination deficiencies (HRD). 

Mechanism of Action

Rucaparib works by inhibiting PARP enzymes (PARP-1, PARP-2, and PARP-3), which are involved in DNA repair through the base excision repair pathway. By blocking these enzymes, rucaparib prevents the repair of single-strand DNA breaks, leading to the accumulation of double-strand breaks.

  • In patients with BRCA mutations or HRD, where DNA repair is already compromised, rucaparib induces synthetic lethality, resulting in cancer cell death.
  • This mechanism is particularly effective in ovarian and prostate cancers that rely on PARP-mediated DNA repair pathways.

Rucaparib is a promising PARP inhibitor that has demonstrated effectiveness in ovarian and prostate cancers, particularly in patients with BRCA mutations. Its mechanism of action makes it a valuable option for patients with homologous recombination deficiency (HRD).

Indications and FDA Approvals

1. Ovarian Cancer

  • Maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy.
  • Treatment of BRCA-mutated ovarian cancer in patients who have received two or more lines of chemotherapy.

2. Prostate Cancer

  • Rucaparib is approved for metastatic castration-resistant prostate cancer (mCRPC) in patients with BRCA1/2 mutations who have received prior androgen receptor-directed therapy and chemotherapy.

3. Other Potential Uses (Under Investigation)

  • Clinical trials are evaluating its efficacy in breast cancer, pancreatic cancer, and other solid tumors with HRD or BRCA mutations.

However, due to potential side effects such as bone marrow suppression, liver toxicity, and secondary cancers, regular monitoring and dose modifications are crucial. With ongoing clinical trials exploring additional indications, rucaparib may expand its role in precision oncology. For patients with platinum-sensitive ovarian cancer or mCRPC, rucaparib provides a targeted, oral treatment option that helps delay disease progression and improve outcomes.

Dosage and Administration

  • The recommended dose of Rucaparib is 600 mg taken orally twice or thrice daily, with or without food as prescribed by the Physician.
  • Treatment should continue until disease progression or unacceptable toxicity occurs.
  • Dose adjustments may be required based on side effects and patient tolerance.

Side Effects of Rucaparib

Common Side Effects

  • Nausea and vomiting
  • Fatigue
  • Decreased appetite
  • Abdominal pain
  • Diarrhea or constipation
  • Anemia
  • Increased liver enzyme levels (ALT/AST)
  • Dysgeusia (altered taste)

Serious Side Effects

  • Myelodysplastic Syndrome (MDS) / Acute Myeloid Leukemia (AML): Rare but potentially life-threatening conditions that require close monitoring.
  • Severe bone marrow suppression: Including thrombocytopenia (low platelets) and neutropenia (low neutrophils).
  • Liver toxicity: Regular liver function tests are advised.
  • Pneumonitis (lung inflammation): Rare but serious side effect requiring discontinuation of treatment.

Warnings and Precautions

1. Hematologic Toxicity

  • Monitor complete blood counts (CBCs) monthly for signs of anemia, neutropenia, or thrombocytopenia.

2. Secondary Cancers (MDS/AML)

  • Patients should be monitored for signs of unexplained bleeding, infection, or persistent fatigue.

3. Liver Function Monitoring

  • Regular assessment of ALT, AST, and bilirubin levels is necessary due to the risk of hepatotoxicity.

4. Pregnancy and Fertility Risks

  • Rucaparib can cause fetal harm; hence, pregnant women should not take this medication.
  • Effective contraception is required during treatment and for 6 months after discontinuation.
  • Male patients with female partners of reproductive potential should use contraception during and for 3 months post-treatment.

Drug Interactions

Rucaparib is metabolized mainly by CYP enzymes (CYP2C19, CYP3A4), so caution is needed when co-administering with drugs that:

  • Increase CYP activity (reduce rucaparib effectiveness): Rifampin, St. John’s Wort.
  • Inhibit CYP activity (increase toxicity risk): Ketoconazole, Clarithromycin.

Patients should inform their healthcare providers about all medications and supplements they are taking to avoid adverse interactions.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration.
  • Time to peak plasma levels: 1.5 to 3 hours post-dose.
  • Metabolism: Primarily via CYP2C19 and CYP3A4 enzymes in the liver.
  • Half-life: Approximately 17-19 hours, allowing twice-daily dosing.
  • Excretion: Mostly in feces (55%) and urine (44%).


Ruparib Benefits & Uses

Ruparib is used to treat the following -

Main Benefits

Ruparib Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult(Female)
  • Disease: Ovarian Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 600 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Ovarian Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 600 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 2 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Ruparib Related Warnings

  • Is the use of Ruparib safe for pregnant women?


    It is not known what effect Ruparib will have on pregnant women, because no research work has been carried out on this till date.

    Unknown
  • Is the use of Ruparib safe during breastfeeding?


    Information about safety of Ruparib for women who are breastfeeding is not available since scientific research on this is yet to be done.

    Unknown
  • What is the effect of Ruparib on the Kidneys?


    Information about safety of Ruparib for kidney is not available since scientific research on this topic is yet to be done.

    Unknown
  • What is the effect of Ruparib on the Liver?


    Side effects of Ruparib on the liver are unknown because research on this has not been conducted yet.

    Unknown
  • What is the effect of Ruparib on the Heart?


    Side effects of Ruparib on heart are unknown because research on this has not been conducted yet.

    Unknown


Severe Interaction of Ruparib with Other Drugs

Ruparib should not be taken with following medicines due to severe side effects it may cause to patients -

Moderate



Ruparib Contraindications

If you are suffering from any of the following diseases, you should not take Ruparib unless your doctor advises you to do so -



Frequently asked Questions about Ruparib

  • Is this Ruparib habit forming or addictive?


    Ruparib is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    You may feel sleepy or tired after taking Ruparib. So it is best to avoid driving.

    Dangerous
  • Is it safe?


    Yes, but take Ruparib only as per medical advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Ruparib is not used to treat mental disorders.

    No

Ruparib Interactions with Food and Alcohol

  • Interaction between Food and Ruparib


    Due to the absence of research, it is difficult to say how Ruparib and food will interact.

    Unknown
  • Interaction between Alcohol and Ruparib


    No research has been done on this till date. Therefore, it is not known what the effect of taking Ruparib with alcohol will be.

    Unknown


See all substitutes for Ruparib


This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience


References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Rubraca® (rucaparib)

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1116-1117



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