Dr. Sameer Awadhiya MBBS , Pediatrics

Lorphen contains chloramphenicol which is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It works by inhibiting the protein synthesis in bacteria which needs to survive. In the absence of protein, the bacterial growth is stunned and slowed. It can also kill the bacteria in higher doses. Lorphen is effective against a wide range of both gram negative and gram positive bacteria such as Salmonella species, Rickettsia species, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, and Staphylococcus pneumoniae.

Dr. MBBS , Pediatrics, Dermatology, General Physician, Dietician, Infectious Disease, Sexual Medicine & Marital Therapy, Obstetrics & Gynaecology, AIDS/HIV Sexually Transmitted Infections

Yes, Lorphen might cause aplastic anemia which is a type of anemia in which the body is not able to make new red blood cells. Lorphen induces aplastic anemia by suppressing the red bone marrow which produces new red blood cells. However, it is reversible and the red blood cells production by red bone marrow is restored after discontinuation of this drug.

Dr. Braj Bhushan Ojha BAMS , Gastroenterology, Dermatology, Psychiatry, Ayurveda, Sexology, Diabetology

No, Lorphen does not contain penicillin. It contains chloramphenicol which belongs to the class of drugs known as amphenicols. It is a broad spectrum antibiotic which covers a wide range of bacteria which are generally found to be resistant to penicillin. It is also used for those patients who are allergic to penicillin and are suffering from the serious bacterial infection.

Dr. Sameer Awadhiya MBBS , Pediatrics

Lorphen is a brand name of chloramphenicol and it comes in the various dosage forms such as an oral tablet, capsule, syrup, and eye drops. It is a prescription drug that belongs to the class of medications called amphenicols. It is a broad spectrum antibiotic which is active against a wide variety of gram-positive and gram-negative bacteria. It is mainly used in the treatment of psittacosis also known as parrot fever, rickettsial infection, cystic fibrosis, pneumonia, and also sometimes in the management of typhoid fever.

Dr. Tarun kumar MBBS , Other

Yes, Lorphen may cause gray baby syndorme in newborn infants especially in premature baby, if this drug is given in higher doses. Gray baby syndrome is a rare side effect that occurs due to accumulation of the chloramphenicol in the newborn infant. The cause of gray baby syndrome is that the newborn baby lacks the some liver enzymes which are necessary to metabolize and removes this drug from the body. The accumulation of the chloramphenicol in the body leads to toxicity which causes development of symptoms such as vomiting, gray color of the skin, blue discolouration of lips and skin. To avoid gray baby syndrome the doses of Lorphen must be lowered and adjusted as per the need.