Bevicra 400mg Injection

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16ml Injection in 1 Vial Out of Stock
₹ 30000
16ml Injection 1 Vial ₹ 30000
  • Out of Stock

Bevicra 400mg Injection

16ml Injection in 1 Vial
₹ 30000
16ml Injection | 1 Vial
₹ 30000
0 people have bought this recently

Bevicra 400mg Injection Information

Bevicra is a monoclonal antibody used in the treatment of various cancers. It works by inhibiting angiogenesis, the process by which tumors develop new blood vessels to sustain their growth. Bevicra specifically binds to vascular endothelial growth factor (VEGF), a protein that promotes the formation of new blood vessels. By neutralizing VEGF, Bevicra starves tumors of their blood supply, inhibiting growth and progression. 

Indications:

  • Colorectal Cancer: Advanced or metastatic stages, often in combination with chemotherapy.
  • Non-Small Cell Lung Cancer (NSCLC): Metastatic cases, in combination with chemotherapy.
  • Renal Cell Carcinoma (RCC): Advanced stages, often combined with interferon alfa.
  • Cervical Cancer: Persistent, recurrent, or metastatic cases.
  • Glioblastoma: As a second-line treatment.
  • Ovarian Cancer: Platinum-resistant and recurrent forms.

Bevicra is a cornerstone in targeted cancer therapy due to its innovative approach to halting tumor growth. However, its use requires careful consideration of patient-specific factors and potential side effects. Collaborating with oncologists and monitoring during treatment ensures the best outcomes for patients.

Side Effects: Hypertension (high blood pressure), Fatigue, Nausea and vomiting, Nosebleeds, Proteinuria (protein in the urine), 

Severe side effects: Gastrointestinal perforations, Hemorrhage, Arterial thromboembolism, Nephrotic syndrome.

Contraindications

  • Hypersensitivity to Bevicra or its components
  • Active infections or significant recent surgical procedures
  • Uncontrolled hypertension

Precautions

  • Pregnancy and Lactation: Bevicra may harm the fetus; effective contraception is advised during and after treatment.
  • Wound Healing: Therapy should be delayed in patients undergoing major surgery.
  • Monitoring: Regular monitoring of blood pressure, kidney function, and signs of bleeding is essential.

Formulation: Bevicra is available as an intravenous infusion.

Typical Dosing: Colorectal Cancer: 5-10 mg/kg every 2 weeks.

NSCLC: 15 mg/kg every 3 weeks.

Dosage varies based on the cancer type, patient condition, and combination regimen.

Storage and Handling

  • Store Bevicra vials at 2°C to 8°C (36°F to 46°F).
  • Do not freeze or shake the vials.
  • Use the prepared solution immediately or within the recommended timeframe.


Bevicra 400mg Injection Benefits & Uses

Bevicra 400mg Injection is used to treat the following -

Main Benefits

Other Benefits

Bevicra 400mg Injection Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Kidney Cancer
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 10 mg/kg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Adult(Female)
  • Disease: Ovarian Cancer
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 10 mg/kg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Kidney Cancer
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 10 mg/kg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: As directed by the doctor
  • Special Instructions: As prescribed by the doctor

Bevicra 400mg Injection Related Warnings

  • Is the use of Bevicra 400mg Injection safe for pregnant women?


    Bevicra can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Bevicra 400mg Injection safe during breastfeeding?


    Women who are breastfeeding, may experience serious side effects after taking Bevicra. So it is adviced to consult the doctor before using it.

    Severe
  • What is the effect of Bevicra 400mg Injection on the Kidneys?


    Kidney can be affected by Bevicra. If you experience any unwanted effects of this drug, stop taking it. You should take it again only after medical advice.

    Moderate
  • What is the effect of Bevicra 400mg Injection on the Liver?


    Bevicra may cause harmful effects on liver. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate
  • What is the effect of Bevicra 400mg Injection on the Heart?


    There may be an adverse effect on the heart after taking Bevicra. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.

    Moderate


Severe Interaction of Bevicra 400mg Injection with Other Drugs

Bevicra 400mg Injection should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Bevicra 400mg Injection Contraindications

If you are suffering from any of the following diseases, you should not take Bevicra 400mg Injection unless your doctor advises you to do so -



Frequently asked Questions about Bevicra 400mg Injection

  • Is this Bevicra 400mg Injection habit forming or addictive?


    Forming a habit of Bevicra 400mg Injection has not been reported.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Bevicra 400mg Injection can make you feel drowsy.

    Dangerous
  • Is it safe?


    Bevicra 400mg Injection is safe but it is important to consult a doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Bevicra 400mg Injection is not used to treat mental disorders.

    No

Bevicra 400mg Injection Interactions with Food and Alcohol

  • Interaction between Food and Bevicra 400mg Injection


    Taking Bevicra 400mg Injection with food does not harm your health.

    Safe
  • Interaction between Alcohol and Bevicra 400mg Injection


    Due to lack of research, there is no information about the side effects of taking Bevicra 400mg Injection with alcohol.

    Unknown


See all substitutes for Bevicra



This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience



References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 224-225

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Avastin® (bevacizumab)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Avastin® (bevacizumab)



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