Nindalieva, containing the active ingredient Nintedanib, is a tyrosine kinase inhibitor used primarily for the treatment of fibrotic lung diseases. It helps slow the progression of conditions like idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated interstitial lung disease (SSc-ILD), and other chronic fibrotic lung disorders.

Uses

• Idiopathic Pulmonary Fibrosis (IPF): Reduces disease progression and slows lung function decline.

• Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Reduces lung fibrosis.

• Chronic Fibrosing Interstitial Lung Diseases with a Progressive Phenotype (PF-ILD): Slows lung function decline.

Mechanism of Action

Nintedanib is a multiple tyrosine kinase inhibitor that targets receptors involved in the regulation of fibrotic processes, including VEGFR, FGFR, and PDGFR. By inhibiting these receptors, it helps reduce fibroblast proliferation, a key factor in lung fibrosis.

Dosage

• Standard Dosage: 150 mg orally twice daily approximately 12 hours apart.

• Dosage Adjustments: Reduce to 100 mg twice daily if adverse reactions occur.

• Take with food and swallow capsules whole with water.

Side Effects

• Common Side Effects: Diarrhea, nausea, abdominal pain, and decreased appetite.

• Serious Side Effects: Liver enzyme elevations, bleeding, and gastrointestinal perforations.

Precautions

• Liver Function Monitoring: Regularly monitor liver enzymes.

• Bleeding Risk: Use cautiously in patients with bleeding disorders.

• Gastrointestinal Health: Monitor for signs of perforation.

• Contraception: Women of childbearing potential should use effective contraception.

Onset and Duration of Action

• Onset of Action: Initial effects on slowing disease progression may be observed within a few months.

• Duration of Action: Therapeutic effects last as long as the medication is continued.

Contraindications

• Hypersensitivity to Nintedanib or any component of the formulation.

• Severe liver impairment.

Storage

• Store at 15°C to 30°C (59°F to 86°F).

• Protect from moisture and light.