Irinot contains Irinotecan, a chemotherapy drug used primarily in the treatment of advanced colorectal cancer. It belongs to a class of medications known as topoisomerase I inhibitors.

Composition

• Active Ingredient: Irinotecan Hydrochloride

• Form: Injectable

• Strength: Available in varying doses as per the prescription

Mechanism of Action
Irinotecan works by inhibiting the topoisomerase I enzyme, which is essential for DNA replication. This inhibition leads to DNA strand breaks and ultimately results in cancer cell death.

Uses

• Treatment of metastatic colorectal cancer (often in combination with other drugs)

• Sometimes used for other cancers as determined by a healthcare provider

Dosage and Administration

• The dosage depends on the patient’s condition, body surface area (BSA), and treatment regimen.

• It is administered as an intravenous infusion.

Common Dosage Regimen

• Monotherapy: 350 mg/m² every 3 weeks

• Combination Therapy: 180 mg/m² every 2 weeks with fluorouracil and leucovorin

Onset of Action

• Initial response to therapy can be observed within 2-3 weeks.

Duration of Action

• The half-life of Irinotecan is approximately 6-12 hours.

Side Effects

• Common: Diarrhea, nausea, vomiting, abdominal pain

• Serious: Severe neutropenia, dehydration, allergic reactions

Precautions

• Avoid use in patients with severe liver impairment.

• Patients should be monitored for severe diarrhea and dehydration.

• Caution in pregnant and breastfeeding women.

Storage

• Store below 25°C (77°F).

• Protect from light.